Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids

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Meibomian gland studies: comparison of steer and human lipids.

Simple surgery gave whole meibomian glands of steer yielding approximately 47 mg of lipid per pair of lids. This lipid gave a thin-layer chromatography pattern similar to that of steer or human excreta. Column chromatography of pooled steer gland lipids and pooled human lipid (excreta) gave 0.06% and 7.54% hydrocarbons, respectively, containing no squalene. Excluding human hydrocarbons (as exog...

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Complete androgen insensitivity syndrome: effect on human meibomian gland secretions.

OBJECTIVE To determine whether androgen receptors affect the fatty acid profiles of neutral and polar lipids in human meibomian gland secretions. METHODS Meibomian gland secretion samples were obtained from both eyes of (1) women with complete androgen insensitivity syndrome, a condition characterized by dysfunctional androgen receptors, and (2) age-matched female and male controls. Samples w...

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Surfactant properties of human meibomian lipids.

PURPOSE Human meibomian lipids are the major part of the lipid layer of the tear film. Their surfactant properties enable their spread across the aqueous layer and help maintain a stable tear film. The purpose of this study was to investigate surfactant properties of human meibomian lipids in vitro and to determine effects of different physical conditions such as temperature and increased osmol...

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Antimicrobial role of human meibomian lipids at the ocular surface.

PURPOSE Human meibomian lipids form the outermost lipid layer of the tear film and serve many important functions to maintain its integrity. Although not investigated earlier, these lipids may have antimicrobial properties that help in strengthening the innate host defense of tears at the ocular surface. The aim of this study was to investigate the antimicrobial role of human meibomian lipids. ...

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Growth of meibomian gland tissue after intraductal meibomian gland probing in patients with obstructive meibomian gland dysfunction

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ژورنال

عنوان ژورنال: Progress in Lipid Research

سال: 2011

ISSN: 0163-7827

DOI: 10.1016/j.plipres.2011.03.003